The Science of Buffering

An in-depth look at buffering local anesthetics.

Leveraging the science of buffering increases the predictability and speed at which a patient can get numb. This in turn can create a better patient experience and increases the efficiency of a practitioner.

The Benefits of Buffering Local Anesthetics


Buffering can elevate the depth of anesthesia increasing the likelihood of patients getting numb the first time.


Buffered anesthetics can cross the nerve membrane more readily allowing a patient to become numb quickly without you having to leave their side.

Reduced Pain

Mixing anesthetic with sodium bicarbonate creates a bi-product of CO2 which by itself contains the ability to create a numbing effect.

What is Buffering?

Buffering is a chemical process that neutralizes acids and bases. The Anutra Local Anesthetic Delivery System utilizes buffering to bring the pH of lidocaine with epinephrine closer to the physiological pH by precisely mixing the anaesthetic with sodium bicarbonate.

Understanding Local Anesthetics

Unbuffered Lidocaine with Epinephrine

Lidocaine with Epinephrine is a local anesthetic commonly used by medical professionals. In order for it to be stabilized to ship, hydrochloric acid is added. In turn, this means that the solution being injected into a patient’s body is very acidic. Not only can this leave a burning or stinging sensation, it can take a good deal of time to numb the patient with a possibility that the patient may not even get numb the first time.

Buffered Lidocaine with Epinephrine

By adding sodium bicarbonate to lidocaine with epinephrine, a medical professional is able to reduce the amount of acidity found in unbuffered lidocaine. The result of buffering lidocaine with epinephrine can increase a clinician’s efficiency and can also reduce a patient’s pain. There is an increased likelihood that a patient will become numb more quickly and be numbed more deeply with buffered anesthetics.

Read studies and the detailed science on buffering?